iS CLINICAL Active Serum vs Super Serum Advance+

Serums have become a cornerstone in modern skincare routines due to their high concentration of active ingredients designed to target specific skin concerns—from acne and hyperpigmentation to fine lines and aging. But with a wide array of choices, how do you find the right one for your skin goals?

In this article, we’ll compare two of iS CLINICAL’s best-selling serums: Active Serum and Super Serum Advance+. Both are scientifically formulated and well-known for delivering visible results, but they serve different purposes.

We’ll explore their ingredients, texture, usage recommendations, and pricing—giving you all the information needed to confidently choose the serum that best suits your skincare needs.

What You’ll Learn:

  • What are iS CLINICAL Active Serum and Super Serum Advance+?
  • What are their key ingredients?
  • How do the textures compare?
  • How should each product be used?
  • What’s the price difference?
  • Which serum is right for you?

About iS CLINICAL Active Serum & Super Serum Advance+

iS CLINICAL, an American skincare brand founded in 2002, is globally respected for blending botanical ingredients with cutting-edge science. Their products are clean, clinical, and suitable for all genders and most skin types.

Active Serum

This fast-acting, results-driven formula is highly praised for its ability to:

  • Reduce fine lines and wrinkles
  • Brighten dull skin
  • Improve uneven skin tone
  • Help acne-prone and congested skin

Its exfoliating and clarifying properties make it ideal for oily, combination, and blemish-prone skin types.

Super Serum Advance+

This advanced anti-aging serum is packed with antioxidants and collagen-boosting ingredients to:

  • Fade dark spots
  • Diminish wrinkles and fine lines
  • Improve skin tone and texture
  • Stimulate collagen production

Super Serum Advance+ is ideal for those looking to address signs of aging, scarring, and discoloration.

Both are fungal-acne safe, reef-safe, and formulated to deliver real, visible results. However, they differ significantly in their ingredient profiles and targeted benefits.

Ingredients Breakdown

iS CLINICAL Active Serum

Formulated with botanical actives, this serum includes:

  • Bilberry Extract: A natural AHA that exfoliates while moisturizing.
  • Arbutin: Derived from mushrooms, helps brighten skin and reduce dark spots.
  • Sugar Cane Extract: A gentle AHA for smoother skin texture.
  • White Willow Bark: A botanical BHA that unclogs pores and refines skin.

These ingredients work synergistically to exfoliate, hydrate, and brighten the complexion without harsh chemicals.

iS CLINICAL Super Serum Advance+

A high-performance blend with 15% L-Ascorbic Acid (Vitamin C), this serum also includes:

  • Advance+ Vitamin C: A stable, potent antioxidant that protects and brightens.
  • Centella Asiatica: A soothing plant extract that targets early aging signs.
  • Copper Tripeptide-1 (Tripeptide-1): Stimulates collagen and smooths fine lines.
  • Mushroom Extract: Natural antimicrobial that enhances clarity and brightness.

Additional ingredients include Hyaluronic Acid, Zinc Sulfate, Arbutin, Glucose, and Pentylene Glycol—each enhancing the serum’s overall effectiveness.

Texture & Absorption

iS CLINICAL Active Serum

  • Consistency: Very lightweight and water-like
  • Absorption: Fast-absorbing; dries down quickly without residue
  • Feel: Produces a mild tingling sensation (from menthol), indicating active absorption
  • Scent: Noticeable alcohol and menthol aroma

iS CLINICAL Super Serum Advance+

  • Consistency: Thin, watery, and easily spreadable
  • Absorption: Quick to absorb, though some users find it tricky to measure even application due to its water-like texture
  • Feel: Smooth and gentle on the skin
  • Scent: Mostly odorless, though some detect a faint plant or witch hazel aroma

Ideal Usage

How to Use Active Serum

Best for normal, combination, oily, and acne-prone skin.

  • Use 3–4 drops on clean skin
  • Apply with fingertips to face and neck
  • Use morning and/or evening
  • Expect a mild tingling sensation
  • Avoid if your skin is very dry or extremely sensitive

How to Use Super Serum Advance+

Ideal for mature, dry, or pigmentation-prone skin.

  • Apply 3–4 drops on clean skin
  • Dab evenly on face and neck
  • Use once or twice daily (AM and/or PM)
  • Follow with moisturizer and sunscreen in the morning

Storage tip: Since it contains Vitamin C, keep the Super Serum Advance+ in a cool, dark place (preferably refrigerated) to prevent oxidation.

Price Comparison

ProductSizeApprox. Price
Active Serum15ml$88
30ml$142
Super Serum Advance+15ml$95
30ml$158

While Super Serum Advance+ is slightly more expensive, its higher cost is justified by its potent antioxidant profile and inclusion of bioidentical growth factors.

Final Verdict: Which Serum Should You Choose?

Both iS CLINICAL Active Serum and Super Serum Advance+ offer outstanding performance, but your choice depends on your specific skin goals:

ConcernRecommended Serum
Acne & congested poresActive Serum
Dull or uneven skin toneBoth
Anti-aging (fine lines, wrinkles)Super Serum Advance+
Sensitive or dry skinSuper Serum Advance+
Exfoliation & brighteningActive Serum

Key Takeaway:

  • Choose Active Serum if you want a lightweight, exfoliating formula to fight acne, brighten skin, and improve clarity.
  • Choose Super Serum Advance+ if you’re targeting signs of aging, dark spots, or scarring, and want powerful antioxidants like Vitamin C and Copper Tripeptide.

Both serums reflect iS CLINICAL’s science-driven approach to skincare, so whether you pick one or use them as complementary treatments, you’re investing in proven results.

iS CLINICAL Active Serum vs Super Serum Advance+

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