If your skincare goals include hydration, brightening, soothing, or gentle exfoliation, two standout serums from iS CLINICAL may be just what you need: iS CLINICAL Active Serum and iS CLINICAL Hydra-Cool Serum. These best-selling formulas come from a trusted skincare brand known for combining the power of nature with cutting-edge science to deliver visible results.
But what sets these serums apart? And which one is better suited for your unique skin type and concerns? In this comprehensive comparison, we’ll explore their ingredients, texture, ideal usage, and pricing—helping you make a confident, informed choice.
In This Article:
- What Are iS CLINICAL Active Serum and Hydra-Cool Serum?
- Key Ingredients Comparison
- Texture and Sensory Experience
- Recommended Usage
- Price Differences
- Final Verdict: Which Serum Should You Choose?
Overview: iS CLINICAL Active Serum vs Hydra-Cool Serum
iS CLINICAL is a U.S.-based skincare brand celebrated for its performance-driven, clinically validated products. Loved by dermatologists, estheticians, and celebrities, iS CLINICAL formulas are designed to target a range of skin concerns using botanically based, pharmaceutical-grade ingredients.
iS CLINICAL Active Serum
This award-winning serum is known for its multi-tasking abilities. It’s fast-acting and results-driven, helping to minimize the appearance of fine lines and wrinkles, even out skin tone, and reduce blemishes. Thanks to its exfoliating and brightening effects, it’s a top pick for those with acne-prone, oily, or congested skin.

iS CLINICAL Hydra-Cool Serum
Formulated to hydrate, calm, and replenish, the Hydra-Cool Serum is a cooling treatment enriched with antioxidants and botanicals. It’s ideal for all skin types—including sensitive and irritated skin—offering intense hydration and soothing effects without clogging pores.

While both products deliver powerful skincare benefits, they’re crafted for different skin needs. Let’s break down the differences further.
Ingredients Breakdown
iS CLINICAL Active Serum Ingredients
This serum is powered by a blend of botanical actives, including:
- Bilberry Extract – A natural AHA with moisturizing and exfoliating properties.
- Arbutin – A brightening agent derived from mushrooms, helping to reduce the appearance of uneven skin tone.
- Sugar Cane Extract – An AHA that exfoliates gently for a renewed complexion.
- White Willow Bark – A botanical BHA that exfoliates and clears clogged pores.
Together, these ingredients provide gentle exfoliation, clarity, and brightening, making the Active Serum highly effective for dull or acne-prone skin.
iS CLINICAL Hydra-Cool Serum Ingredients
This serum features a potent mix of hydrating and soothing ingredients:
- Centella Asiatica – Known for its healing properties, it helps combat signs of premature aging.
- Hyaluronic Acid – A powerhouse hydrator that deeply moisturizes and plumps the skin.
- Mushroom Extract – A natural antimicrobial that supports a clearer and more radiant complexion.
- Vitamin B5 – An essential nutrient for healthy skin metabolism, promoting softness and resilience.
- Menthol – Adds a cooling, refreshing sensation and soothes irritated skin.
These ingredients work synergistically to hydrate, nourish, and calm the skin—especially beneficial for redness, sunburn, or post-procedure care.
Texture & Scent Experience
Active Serum Texture & Feel
The Active Serum has a lightweight, watery consistency that absorbs quickly and leaves the skin feeling smooth and refreshed. Many users report a tingling sensation, which is a normal response due to the product’s active ingredients like menthol and botanical acids. This tingling signals that the formula is working to exfoliate and clarify the skin.
Scent: It has a noticeable scent of alcohol and menthol, which dissipates quickly after application.
Hydra-Cool Serum Texture & Feel
In contrast, the Hydra-Cool Serum has a slightly thicker yet still lightweight gel-like texture, thanks to hyaluronic acid. It glides on smoothly and absorbs fast, delivering an immediate cooling and hydrating effect.
Scent: Technically fragrance-free, but the menthol gives it a mildly refreshing scent.
How to Use iS CLINICAL Serums
Active Serum Usage
Perfect for normal, combination, oily, and acne-prone skin, the Active Serum is best used for:
- Reducing fine lines
- Smoothing skin texture
- Minimizing breakouts
- Evening out skin tone
Application: Apply 3–4 drops to clean, dry skin. Use fingertips to spread evenly over your face and neck. Expect a tingling sensation that fades quickly.
Frequency: Can be used morning and evening, but those with dry or sensitive skin should start slowly.
Hydra-Cool Serum Usage
Hydra-Cool Serum is designed for all skin types and ages, including sensitive or irritated skin. It works well for:
- Soothing post-sunburn or post-shaving skin
- Calming blemishes
- Providing all-day hydration
- Layering with active ingredients like retinol or vitamin C
Application: Use sparingly on clean, dry skin. It can be used alone or layered with other treatments, both AM and PM.
Price Comparison
Product | 15ml Size | 30ml Size |
iS CLINICAL Active Serum | $88 | $142 |
iS CLINICAL Hydra-Cool Serum | $64 | $99 |
While the Active Serum is more expensive, its multi-functional benefits may justify the higher cost. Both are premium skincare investments, but your final decision should align with your skin’s needs.
Final Verdict: Which One Should You Choose?
- Choose iS CLINICAL Active Serum if your focus is on:
- Exfoliation and skin renewal
- Acne control and oil balance
- Targeting signs of aging and dullness
- Opt for iS CLINICAL Hydra-Cool Serum if you need:
- Deep hydration and skin-soothing
- Relief from irritation, redness, or sunburn
- A gentle formula for sensitive or sensitized skin
Both serums are free from fragrances, parabens, oils, silicones, and sulfates, and are fungal acne-safe and reef-safe. They can also be used together—Hydra-Cool in the morning, Active Serum at night—for a complete routine.
In Conclusion:
Whether you’re looking to clarify and brighten or hydrate and calm, iS CLINICAL offers a serum for your specific needs. Consider your skin type, sensitivity level, and goals to choose the perfect formula—and enjoy the visible transformation of healthy, radiant skin.