iS CLINICAL Pro-Heal Serum Advance+ vs Super Serum Advance+

Serums have become a cornerstone of modern skincare routines, praised for delivering targeted and visible results. Among the most talked-about options are iS CLINICAL Pro-Heal Serum Advance+ and iS CLINICAL Super Serum Advance+—two advanced formulas that have gained a loyal following worldwide.

Both products come from iS CLINICAL, a respected brand known for its high-performance, science-backed skincare. But what sets these two serums apart? If you’re debating between them, this guide will walk you through a detailed comparison of their ingredients, textures, usage, and pricing, helping you decide which serum fits your skincare goals best.

Product Overview

iS CLINICAL is a globally recognized skincare brand that combines cutting-edge research with high-quality botanicals to create effective, results-driven formulations. Their products are frequently recommended by dermatologists and estheticians for treating a variety of skin concerns.

iS CLINICAL Pro-Heal Serum Advance+

This powerful antioxidant serum is designed to defend the skin against environmental stressors, brighten dull complexions, and minimize signs of aging. Featuring advanced vitamin C delivery technology, this formula offers impressive healing and protective properties—making it ideal for sensitive or compromised skin.

iS CLINICAL Super Serum Advance+

Super Serum Advance+ is a next-generation anti-aging treatment that combines potent antioxidants with collagen-boosting peptides. It’s clinically proven to reduce fine lines, brighten dark spots, and enhance skin elasticity. This multi-tasking serum is often praised as one of the top anti-aging solutions on the market.

While both serums target fine lines, wrinkles, and skin tone issues, they each offer unique benefits based on their formulation. Let’s take a closer look.

Key Ingredient Comparison

Pro-Heal Serum Advance+ Key Ingredients:

L-Ascorbic Acid (Vitamin C): Calms irritated skin, defends against UV-induced damage.
Vitamin E: Offers antioxidant protection against photodamage.
Retinol (Vitamin A): Smooths skin texture, reduces signs of aging.
Olive Leaf Extract: Helps fight free radical damage and inflammation.
Kojic Acid (from Mushroom Extract): Targets hyperpigmentation.
Zinc Sulfate: Enhances healing, protects against UV damage, and supports immune function.
Additional Ingredients: Arbutin, Tocopherol, Glycerin, Bioflavonoids, and more.

This formula is particularly beneficial for acne-prone, inflamed, or sensitive skin due to its anti-inflammatory and reparative properties.

Super Serum Advance+ Key Ingredients:

15% L-Ascorbic Acid (ADVANCE+ Vitamin C): Brightens and protects while calming the skin.
Copper Tripeptide-1: A growth factor that boosts collagen production and improves skin texture.
Centella Asiatica: Known for its anti-aging and skin-soothing benefits.
Mushroom Extract: Brightens and provides natural antimicrobial support.

Additional ingredients include Hyaluronic Acid, Pentylene Glycol, Arbutin, Zinc Sulfate, Calcium Pantothenate, and more, making this serum ideal for addressing aging skin, uneven tone, and scarring.

Texture & Application Experience

Pro-Heal Serum Advance+ Texture:

This serum has a lightweight, non-greasy, watery consistency, making it absorb easily without leaving residue. Users describe the texture as smooth and moisturizing, with a neutral scent, free from the typical “vitamin C” aroma found in similar products.

Super Serum Advance+ Texture:

Similarly watery and fast-absorbing, Super Serum Advance+ offers a thin texture that quickly penetrates the skin. While this is excellent for quick routines, some users find that the ultra-light consistency makes it harder to judge if it’s been applied evenly.

Fragrance Profile: Technically fragrance-free, although some users report a faint scent of natural botanicals like witch hazel. However, it’s generally considered inoffensive and mild.

How to Use Each Serum

Pro-Heal Serum Advance+

Best for: Sensitive, acne-prone, or inflamed skin (including conditions like rosacea).
How to Use: After cleansing and toning, apply 3–4 drops to your palm. Gently press and smooth over your face and neck. Ideal for morning use, though it can be used in the evening as well.
Key Benefits: Soothes irritation, protects against UV damage, reduces breakouts, and improves aging signs.

Super Serum Advance+

Best for: Anti-aging, dull skin, hyperpigmentation, or raised (hypertrophic) scar tissue.
How to Use: Apply 3–4 drops to clean, dry skin in the morning or evening, after cleansing and before moisturizing. Dab over the face and neck using your fingertips.
Key Benefits: Boosts collagen, fades dark spots, brightens complexion, and firms the skin over time.

Storage Tip: Both serums contain Vitamin C, which is sensitive to light and heat. For maximum efficacy, store in a cool, dark place—preferably a refrigerator—to prevent oxidation.

Price Comparison

Both serums fall within a similar price range, depending on the size and retailer:

Product	15ml Size	30ml Size
Pro-Heal Serum Advance+	$95–$126	$158–$216
Super Serum Advance+	$95–$126	$158–$216

Since the pricing is nearly identical, your decision will largely come down to skin concerns rather than budget.

Final Thoughts: Which Serum Is Right for You?

Choose Pro-Heal Serum Advance+ if your skin is sensitive, acne-prone, irritated, or showing signs of inflammation. Its calming, healing formula is ideal for those with compromised skin barriers.
Go with Super Serum Advance+ if you’re targeting signs of aging, hyperpigmentation, or want to boost collagen and brighten your complexion. It’s a powerful option for smoothing fine lines and enhancing radiance.

Key Takeaway:

Both products are formulated with high-grade ingredients, are dermatologist-approved, and suit a variety of skin types. Since the cost is comparable, the best choice depends on your personal skincare goals.