Finding the perfect skincare product for your specific skin type and concerns can feel overwhelming with so many options available today. One brand that continues to stand out for its clinical approach and high-performance formulas is iS CLINICAL. Two of its most popular serums—Youth Serum and Active Serum—are designed to address different skin issues while promoting overall skin health.
But what makes these serums different, and how do you know which one is right for you? In this article, we’ll compare their ingredients, textures, ideal usage, and pricing to help you make an informed choice for your skincare routine.
What We’ll Cover:
- What are iS CLINICAL Youth Serum and Active Serum?
- Key ingredient comparison
- Texture and absorption
- How to use each serum
- Price comparison
- Which one should you buy?
About iS CLINICAL Youth Serum and Active Serum
iS CLINICAL is renowned for its science-backed, dermatologist-loved formulations made with potent botanical extracts, antioxidants, and pharmaceutical-grade actives. The brand targets various skin concerns such as aging, acne, hyperpigmentation, and sensitivity.
Among its bestselling products are the iS CLINICAL Youth Serum and the iS CLINICAL Active Serum, each designed to deliver visible improvements for different skincare needs.
iS CLINICAL Youth Serum
Youth Serum is a multi-tasking anti-aging solution that provides both instant tightening and long-term firming benefits. It improves the skin’s structure, promotes collagen production, and enhances skin renewal. With continuous use, it helps reduce the appearance of fine lines, wrinkles, and sagging.
iS CLINICAL Active Serum
Active Serum is a results-driven formula ideal for blemish-prone or dull skin. Known for its brightening and clarifying effects, it works to smooth uneven skin tone, reduce breakouts, and minimize signs of aging. It’s often recommended for those dealing with acne, congestion, or discoloration.
While both serums deliver visible results, they cater to different skin concerns, making them complementary in a complete skincare regimen.
Ingredient Comparison: Youth Serum vs Active Serum
Key Ingredients in iS CLINICAL Youth Serum
The Youth Serum combines cutting-edge technology with powerful actives, including:
- Vitamin A, C & E Blend: A liposome-encapsulated antioxidant trio for enhanced absorption and cellular protection.
- Copper Tripeptide Growth Factor (Tripeptide-1): Stimulates skin repair and visibly reduces wrinkles.
- Extremozymes®: A proprietary enzyme complex that shields the skin from environmental stressors.
- Centella Asiatica: A healing botanical that supports skin regeneration and reduces signs of aging.
Additional ingredients include marine extremozyme, wheat and soy proteins, glycerin, and locust bean gum, all working together to nourish and protect the skin.
Key Ingredients in iS CLINICAL Active Serum
The Active Serum focuses on botanical actives with exfoliating and brightening properties:
- Bilberry Extract: A natural AHA with moisturizing and exfoliating benefits.
- Sugar Cane Extract: Gently resurfaces the skin with AHA properties.
- White Willow Bark: A botanical BHA that deeply cleanses pores and exfoliates.
- Arbutin: Derived from mushrooms, helps to reduce uneven skin tone and boost brightness.
These natural ingredients promote smoother, clearer, and more radiant skin with regular use.
Texture & Feel on Skin
Youth Serum Texture
iS CLINICAL Youth Serum has a lightweight, fast-absorbing texture that leaves the skin feeling instantly firmer and smoother. It creates a slight tingling sensation upon application, indicating active ingredients at work. Be cautious not to over-apply, as excess product can cause a mild lather during application.
The serum is fragrance-free or has a very neutral scent, making it suitable for sensitive users or those who dislike strong skincare fragrances.
Active Serum Texture
iS CLINICAL Active Serum has a watery, lightweight consistency that absorbs quickly into the skin. It leaves a smooth, hydrated finish and is praised for its refreshing feel.
It does, however, have a strong menthol and alcohol scent, and you may feel a tingling or stinging sensation shortly after applying. This effect is due to the Mentha extract, signaling the serum’s active ingredients are penetrating the skin.
Ideal Usage: How to Use Each Serum
How to Use iS CLINICAL Youth Serum
Youth Serum delivers both instant results and long-term anti-aging effects. Its advanced actives firm the skin immediately, while ingredients like Copper Tripeptide-1 and Centella Asiatica help to visibly reduce wrinkles over time.
Application tips:
- Use 1–2 drops in the morning or evening on clean, dry skin.
- Gently pat around the face, neck, and eye area.
- Safe for use under makeup or as a midday skin refresh.
How to Use iS CLINICAL Active Serum
Designed for oily, congested, or acne-prone skin, Active Serum exfoliates and brightens while improving overall skin clarity.
Application tips:
- Apply sparingly to clean, dry skin in the evening.
- Smooth a few drops over the face and neck.
- Expect a temporary tingling sensation upon use.
Ideal for: Normal, oily, combination, and blemish-prone skin types.
Price Comparison
Here’s a quick comparison of the pricing:
| Product | Size | Approximate Price |
| iS CLINICAL Youth Serum | 30ml | $159 |
| iS CLINICAL Active Serum | 15ml | $88 |
| 30ml | $142 |
As shown, Youth Serum is the higher-priced option, reflecting its advanced peptide technologies and growth factor ingredients. Active Serum, while still premium, is slightly more affordable and available in two sizes.
Prices may vary depending on retailers, so it’s always smart to check for the latest offers and promotions online.
Which One Should You Choose?
Choose iS CLINICAL Youth Serum if:
- You want immediate firming and long-term anti-aging effects
- You’re targeting fine lines, wrinkles, and loss of firmness
- You prefer a gentle, fragrance-free formula for mature or sensitive skin
Choose iS CLINICAL Active Serum if:
- Your concerns include acne, oiliness, dullness, or uneven skin tone
- You need a serum with brightening and exfoliating benefits
- You enjoy lightweight, fast-absorbing products with active botanical extracts
Final Thoughts
Both iS CLINICAL Youth Serum and Active Serum are standout products backed by science and clinical results. While they serve different purposes, they are equally effective depending on your specific skin concerns.
If you’re focused on anti-aging and skin firmness, Youth Serum is a powerful solution with both instant and lasting results. If you’re looking to clear, brighten, and refine your skin, Active Serum delivers fast-acting clarity with natural botanicals.
No matter which you choose, you’ll be investing in quality skincare that’s trusted by professionals worldwide. Evaluate your goals, skin type, and budget to decide which serum deserves a spot in your routine.